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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2

Fig. 7

CD14/CD1a surface expression and phagocytic capacity of mDCs co-cultured with COX-2 KO or parental ASCs. a COX-2 qPCR (top) and PGE2 ELISA (bottom) of COX-2 KO or parental ASCs in basal conditions or upon IL-1β stimulation (n = 3). b, d Dot plots and graphs showing the surface expression of CD14/CD1a, in monocyte-derived mDCs in the presence or absence of COX-2 KO or parental ASCs, measured by flow cytometry (n = 3). Average positive percentage ± SEM is represented. c, e Histograms and graphs showing the phagocytosis levels of S. aureus by monocyte-derived mDCs, in the presence or absence of COX-2 KO or parental ASCs, measured by flow cytometry (n = 3). Average positive percentage increase versus mDC alone ± SEM is represented. ***p < 0.001, ****p < 0.0001. ASC, adipose-derived mesenchymal stem cell; CD, cluster of differentiation; COX-2, cyclooxygenase 2; Exp, experiment; KO, knock-out; mDC, mature dendritic cell; P, parental; PGE2, prostaglandin E2; S. aureus, Staphylococcus aureus

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