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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation

Fig. 4

Function of NKX6.1 in adult mouse pancreatic β cells. Nkx6.1 regulates the expression of genes encoding for proteins responsible for β cell proliferation (Ccnd2, Glut2, AURKA, c-Fos, Nr4a1, and Nr4a3), β cell development and function (MafA, Mnx1, Rfx6, and Tle3), glucose uptake and metabolism (Glut2, G6pc2, Pcx), and insulin biosynthesis (Ero1lb and Slc30a8)

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Stem Cell Research & Therapy

ISSN: 1757-6512