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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation

Fig. 5

Structural architecture and domain organization of NKX6.1. A schematic representation of NKX6.1, consists of N-terminal repression domain (N), a DNA-binding homeodomain, and a C-terminal activation domain (C). Crystal structure of Aristaless and Clawless homeodomains of drosophila in complex with the DNA (PDBID: 3A01). The two homeodomains (orange and cyan) cooperate in binding onto the DNA (gray). The drosophila homeodomain structure is the closest to NKX6.1 homeodomain

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