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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: miRNA-126-3p carried by human umbilical cord mesenchymal stem cell enhances endothelial function through exosome-mediated mechanisms in vitro and attenuates vein graft neointimal formation in vivo

Fig. 6

Treatment with hucMSCs overexpressing miRNA-126-3p accelerated endothelialization of the vein grafts in an arterialized rat model. Rat vein graft model: external jugular vein into infrarenal aorta (a). The luminal diameter (b) and peak systolic velocity (c) were measured by serial ultrasound studies during the whole study period. d Representative gross morphology of vein grafts at 4 weeks after transplantation. e Representative images of hucMSCs recruitment in the vein grafts, hucMSCs were predominantly found at the intraluminal site of the blood vessel as indicated by CM-Dil and GFP fluorescence. f Vein grafts harvested 2 weeks after hucMSC transplantation were analyzed by CD34 immunohistochemical staining to assess vascular reendothelialization in each group

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