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Table 1 Proteome analysis of selected chemokines in muscle biopsies of CMD-affected patients

From: Congenital muscular dystrophy-associated inflammatory chemokines provide axes for effective recruitment of therapeutic adult stem cell into muscles

Chemokine Fold difference/controla
BM UCMD MDC1A
CCL28 6.6 6.1 7.9
CK beta 8-1 1.7 1.6 2.3
CTACK 1.2 1.2 1.9
CXCL-16 3.2 2.6 5.3
ENA-78 1.6 1.4 3.3
Eotaxin 2.6 2.2 6.2
GCP-2 1099.5 1151.4 1189.1
GRO 2.9 3.1 2.3
GRO-alpha 1.4 2.0 2.1
HCC-4 1.5 1.7 2.2
I-309 1.7 1.4 2.0
I-TAC 2.6 1.7 2.8
IL-8 0.5 0.7 1.2
IP-10 0.8 1.0 1.9
MCP-1 1.8 3.0 2.7
NAP-2 3.3 4.1 5.0
RANTES 1.7 5.7 11.0
  1. aData represented as fold difference of CMD muscle vs healthy (control) muscle. Each protein array was processed in an identical manner and the number represents an average of triplicate experiments from 5 BM, 8 UCMD, and 5 MDC1A muscle samples. Fold difference does not reflect quantity. BM Bethlem myopathy, UCMD Ulrich congenital muscular dystrophy, MDC1A Merosin-deficient congenital muscular dystrophy type 1A