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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes

Fig. 2

Assessment of transcriptomic differences in the trio NPC lines using RNASeq. a, c Principal component and cluster analysis of RPKM values demonstrates a clear separation between RNASeq samples from different members of the trio (N = 4 for clones 1 and N = 3 for clones 2). b Differential gene expression analysis identified significantly upregulated and downregulated genes. d Significantly enriched GO (blue) and PATHWAY (red) terms and fold enrichment values, listed in order of statistical significance (Bonferroni score < 0.05)

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