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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats

Fig. 2

hPD-MSC therapy attenuates ovarian dysfunction by inducing follicular development. a Classification of the ovarian follicular stages used for analysis. The scale bars indicate 50 μm. b Ovarian structure after hPD-MSC therapy. Six rats in each group were randomly selected at the indicated time points following hPD-MSC injection. By histological analyses, serially sectioned whole ovaries were stained with H&E, and follicles at different stages were counted in the control and hPD-MSC therapy groups. Black arrowheads indicate ovarian follicles. Scale bars indicate 1 mm. c After single- or multiple-injection therapy, the numbers of follicles at various stages were counted and compared with the numbers in the control group. hPD-MSC therapy resulted in a significant increase in the number of developmental follicles. The results are presented as the mean ± SEM, and statistical p values were calculated; *p < 0.001, **p < 0.01, and ***p < 0.05. One, single-injection hPD-MSC therapy; Three, multiple-injection hPD-MSC therapy

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