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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats

Fig. 6

Schematic diagram of the modulation of miR-145 expression and BMP-SMAD signaling by hPD-MSC therapies on folliculogenesis. When old female rats were treated with hPD-MSCs, there was a marked reduction in circulating miR-145 levels and restoration of BMP-SMAD1/5 signaling, but not of TGF-β signaling, resulting in the activation of the primordial-to-primary follicle transition. As a result, aged ovaries had increased ovarian reserve and ovarian function

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Stem Cell Research & Therapy

ISSN: 1757-6512