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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Bone marrow mesenchymal stem cell-derived exosomes promote plasminogen activator inhibitor 1 expression in vascular cells in the local microenvironment during rabbit osteonecrosis of the femoral head

Fig. 2

Elevation of PAI-1 in GC-induced rabbit ONFH in vivo. a Organ and bone tissue of the lower extremities in rabbit were tested (n = 5). b Expression of PAI-1 of organs was significantly increased following GC treatment, as shown by qRT-PCR. c Bone tissue from the lower extremities and blood samples presented a significant increase of PAI-1 expression following GC treatment, as shown by qRT-PCR. d PAI-1 concentrations in the femoral head, knee, ankle, and blood samples were remarkably increased after the GC treatment, as shown by ELISA. e Representative immunohistochemical staining of PAI-1 in samples of the femoral head from the control and GC-induced experimental groups. Magnification: ×40. Enlarged images shown in the lower right corner at ×100. Asterisks (*) indicate significant differences (p < 0.05) and **p < 0.01. The results are presented as the means ± s.e.m

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