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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Bone marrow mesenchymal stem cell-derived exosomes promote plasminogen activator inhibitor 1 expression in vascular cells in the local microenvironment during rabbit osteonecrosis of the femoral head

Fig. 7

Functional influence of exosomal miRNAs on regulating PAI-1 expression in GC-induced rabbit ONFH models. a Expression of PAI-1 from the femoral head bone, liver, and peripheral blood samples by qRT-PCR. b PAI-1 concentrations in the femoral head bone, liver, and peripheral blood samples by ELISA. AgomiR-451-5p significantly increased PAI-1 expression in all tested samples. AgomiR-133b-3p significantly decreased PAI-1 expression from GC treatment. c Representative IHC images of PAI-1 staining of the harvested femoral head tissues in different treatment. PAI-1 is expressed in a dark brown color. Magnification: ×50. Enlarged images shown in the lower right corner at ×200. d Representative HE staining images of subchondral bone from femoral head and semi-quantitative analysis. The miR-451-5p group showed significantly more empty lacunae than that in the control group, and compared with the GC group, the miR-133b-3p group showed significantly fewer empty lacunae. Magnification: ×200. Asterisks (*) indicate significant differences (p < 0.05) and **p < 0.01. The results are presented as the means ± s.e.m

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Stem Cell Research & Therapy

ISSN: 1757-6512