Fig. 6

Inhibition of Akt/GSK-3β/Fyn pathway downregulate the expression of Nrf2-regulated antioxidant genes in senescent CD4⁺ T cells. a Nuclear translocation of Nrf2 and Fyn were determined by immunofluorescent staining (bar = 10 μm). b The expressions of Akt/GSK-3β/Fyn pathway in CD4⁺ T cells were evaluated by Western blot. c The ratio of p-Akt/Akt. d The ratio of p-GSK-3β/GSK-3β. e The level of nuclear Fyn. Data represent the mean scores ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01