Fig. 7

Inhibition of Akt/GSK-3β/Fyn pathway impairs the protective effects of hPMSCs in senescent CD4⁺ T cells. a, b The percentages of SA-β-gal-positive CD4⁺ T cells are shown (bar = 10 μm). c, e The expression of ROS in CD4⁺ T cells. f–h The antioxidant enzyme activity of SOD, CAT, and GSH-Px in CD4⁺ T cells. i, j The expressions of senescent markers P16 and P21 in CD4⁺ T cells. k The mRNA expressions of IL-6 and OPN in CD4⁺ T cells. Data represent the mean scores ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01