Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study

Kassem, Dina H.; Kamal, Mohamed M.

doi:10.1186/s13287-020-01996-x

Stem Cell Research & Therapy

Table 2 Summary of the meta-analyses done for enrolled subjects before and after receiving umbilical cord-derived stem cell transplantation

From: Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study

Study name and year	Number of subjects	After SC		Number of subjects	Before SC		Study Weight (%)	SMD	Lower CI	Upper CI	Type of DM	Type of UC-SC
Study name and year	Number of subjects	Mean	SD	Number of subjects	Mean	SD	Study Weight (%)	SMD	Lower CI	Upper CI	Type of DM	Type of UC-SC
HbA1c%
Hu et al., 2013	15	6.100	1.100	15	6.850	2.200	19.9	− 0.420	− 1.143	0.304	T1DM	WJ-MSCs
Hu et al., 2016	31	6.000	0.700	31	7.670	1.230	25.1	− 1.648	− 2.224	− 1.072	T2DM	WJ-MSCs
Liu et al., 2014	22	7.000	0.600	22	8.200	1.690	23.3	− 0.929	− 1.551	− 0.307	T2DM	WJ-MSCs
Guan et al., 2015	6	6.500	1.850	6	8.550	1.450	9.7	− 1.138	− 2.358	0.082	T2DM	WJ-MSCs
Cai et al., 2016	21	7.500	1.000	21	8.600	0.810	22.1	− 1.186	− 1.842	−0.530	T1DM	WJ-MSCs
Haller et al., 2013	10	7.100	1.290	10	7.067	1.290	17.1	0.024	−0.852	0.901	T1DM	UCB
Giannopoulou et al., 2013	7	7.250	0.440	7	7.025	0.840	11.8	0.314	− 0.740	1.368	T1DM	UCB
Haller et al., 2011	24	7.200	0.870	24	7.430	1.497	40.9	− 0.185	− 0.752	0.382	T1DM	UCB
Haller et al., 2009	15	7.067	0.980	15	7.130	1.799	25.6	− 0.042	− 0.758	0.673	T1DM	UCB
Tong et al., 2013	3	7.170	0.420	3	10.530	3.720	4.5	− 1.013	− 2.713	0.687	T2DM	UCB
C-peptide levels (ng/ml)
Hu et al., 2013 ^a	15	1.350	0.230	15	0.850	1.820	20.3	0.375	− 0.347	1.097	T1DM	WJ-MSCs
Hu et al., 2016 ^a	31	2.660	0.330	31	1.750	0.640	23.2	1.765	1.178	2.352	T2DM	WJ-MSCs
Liu et al., 2014 ^a	22	1.860	1.000	22	1.290	0.830	22.8	0.609	0.005	1.214	T2DM	WJ-MSCs
Guan et al., 2015 ^a	6	2.120	1.250	6	1.030	0.300	12.1	1.107	− 0.109	2.322	T2DM	WJ-MSCs
Cai et al., 2016 ^a	21	0.060	0.030	21	0.030	0.020	21.7	1.154	0.501	1.808	T1DM	WJ-MSCs
Haller et al., 2013 ^{b, *}	10	0.160	0.180	10	0.360	0.240	19.1	− 0.903	− 1.823	0.017	T1DM	UCB
Giannopoulou et al., 2013 ^b	7	0.390	0.388	7	0.945	0.540	13.9	− 1.105	− 2.230	0.020	T1DM	UCB
Haller et al., 2011^b	24	0.400	0.550	24	1.190	0.800	33.2	− 1.132	− 1.741	− 0.523	T1DM	UCB
Haller et al., 2009 ^b	15	0.690	0.850	15	1.220	1.090	26.6	− 0.528	− 1.256	0.200	T1DM	UCB
Tong et al., 2013 ^a	3	2.040	1.050	3	1.300	0.320	7.1	0.761	− 0.896	2.418	T2DM	UCB
Insulin daily requirement (IU/Kg/day)
Hu et al., 2013 ^#	15	20.700	11.100	15	37.800	4.600	20.1	− 1.958	− 2.829	− 1.088	T1DM	WJ-MSCs
Hu et al., 2016 ^#	31	12.000	3.000	31	45.900	8.900	19.4	− 5.040	− 6.058	− 4.023	T2DM	WJ-MSCs
Liu et al., 2014	22	0.230	0.190	22	0.490	0.220	20.9	− 1.242	− 1.888	− 0.597	T2DM	WJ-MSCs
Guan et al., 2015	6	0.280	0.350	6	0.430	0.220	18.8	− 0.473	− 1.621	0.674	T2DM	WJ-MSCs
Cai et al., 2016	21	0.600	0.200	21	0.900	0.200	20.8	− 1.472	− 2.154	− 0.790	T1DM	WJ-MSCs
Haller et al., 2013	10	0.640	0.150	10	0.340	0.198	19.5	1.636	0.623	2.648	T1DM	UCB
Giannopoulou et al., 2013	7	0.790	0.410	7	0.660	0.470	18.8	0.276	− 0.777	1.329	T1DM	UCB
Haller et al., 2011	24	0.680	0.200	24	0.370	0.230	26.8	1.415	0.782	2.047	T1DM	UCB
Haller et al., 2009	15	0.660	0.180	15	0.390	0.280	24.0	1.116	0.347	1.885	T1DM	UCB
Tong et al., 2013	3	0.320	0.210	3	0.525	0.130	10.9	− 0.937	− 2.622	0.749	T2DM	UCB

^aFasting C-peptide
^bStimulated peak C-peptide
^*Measuring unit; pmol/L
^#Measuring unit; IU/day

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