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Table 2 Summary of the meta-analyses done for enrolled subjects before and after receiving umbilical cord-derived stem cell transplantation

From: Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study

Study name and year Number of subjects After SC Number of subjects Before SC Study Weight (%) SMD Lower CI Upper CI Type of DM Type of UC-SC
Mean SD Mean SD
HbA1c%
 Hu et al., 2013 15 6.100 1.100 15 6.850 2.200 19.9 − 0.420 − 1.143 0.304 T1DM WJ-MSCs
 Hu et al., 2016 31 6.000 0.700 31 7.670 1.230 25.1 − 1.648 − 2.224 − 1.072 T2DM WJ-MSCs
 Liu et al., 2014 22 7.000 0.600 22 8.200 1.690 23.3 − 0.929 − 1.551 − 0.307 T2DM WJ-MSCs
 Guan et al., 2015 6 6.500 1.850 6 8.550 1.450 9.7 − 1.138 − 2.358 0.082 T2DM WJ-MSCs
 Cai et al., 2016 21 7.500 1.000 21 8.600 0.810 22.1 − 1.186 − 1.842 −0.530 T1DM WJ-MSCs
 Haller et al., 2013 10 7.100 1.290 10 7.067 1.290 17.1 0.024 −0.852 0.901 T1DM UCB
 Giannopoulou et al., 2013 7 7.250 0.440 7 7.025 0.840 11.8 0.314 − 0.740 1.368 T1DM UCB
 Haller et al., 2011 24 7.200 0.870 24 7.430 1.497 40.9 − 0.185 − 0.752 0.382 T1DM UCB
 Haller et al., 2009 15 7.067 0.980 15 7.130 1.799 25.6 − 0.042 − 0.758 0.673 T1DM UCB
 Tong et al., 2013 3 7.170 0.420 3 10.530 3.720 4.5 − 1.013 − 2.713 0.687 T2DM UCB
C-peptide levels (ng/ml)
 Hu et al., 2013 a 15 1.350 0.230 15 0.850 1.820 20.3 0.375 − 0.347 1.097 T1DM WJ-MSCs
 Hu et al., 2016 a 31 2.660 0.330 31 1.750 0.640 23.2 1.765 1.178 2.352 T2DM WJ-MSCs
 Liu et al., 2014 a 22 1.860 1.000 22 1.290 0.830 22.8 0.609 0.005 1.214 T2DM WJ-MSCs
 Guan et al., 2015 a 6 2.120 1.250 6 1.030 0.300 12.1 1.107 − 0.109 2.322 T2DM WJ-MSCs
 Cai et al., 2016 a 21 0.060 0.030 21 0.030 0.020 21.7 1.154 0.501 1.808 T1DM WJ-MSCs
 Haller et al., 2013 b, * 10 0.160 0.180 10 0.360 0.240 19.1 − 0.903 − 1.823 0.017 T1DM UCB
 Giannopoulou et al., 2013 b 7 0.390 0.388 7 0.945 0.540 13.9 − 1.105 − 2.230 0.020 T1DM UCB
 Haller et al., 2011b 24 0.400 0.550 24 1.190 0.800 33.2 − 1.132 − 1.741 − 0.523 T1DM UCB
 Haller et al., 2009 b 15 0.690 0.850 15 1.220 1.090 26.6 − 0.528 − 1.256 0.200 T1DM UCB
 Tong et al., 2013 a 3 2.040 1.050 3 1.300 0.320 7.1 0.761 − 0.896 2.418 T2DM UCB
Insulin daily requirement (IU/Kg/day)
 Hu et al., 2013 # 15 20.700 11.100 15 37.800 4.600 20.1 − 1.958 − 2.829 − 1.088 T1DM WJ-MSCs
 Hu et al., 2016 # 31 12.000 3.000 31 45.900 8.900 19.4 − 5.040 − 6.058 − 4.023 T2DM WJ-MSCs
 Liu et al., 2014 22 0.230 0.190 22 0.490 0.220 20.9 − 1.242 − 1.888 − 0.597 T2DM WJ-MSCs
 Guan et al., 2015 6 0.280 0.350 6 0.430 0.220 18.8 − 0.473 − 1.621 0.674 T2DM WJ-MSCs
 Cai et al., 2016 21 0.600 0.200 21 0.900 0.200 20.8 − 1.472 − 2.154 − 0.790 T1DM WJ-MSCs
 Haller et al., 2013 10 0.640 0.150 10 0.340 0.198 19.5 1.636 0.623 2.648 T1DM UCB
 Giannopoulou et al., 2013 7 0.790 0.410 7 0.660 0.470 18.8 0.276 − 0.777 1.329 T1DM UCB
 Haller et al., 2011 24 0.680 0.200 24 0.370 0.230 26.8 1.415 0.782 2.047 T1DM UCB
 Haller et al., 2009 15 0.660 0.180 15 0.390 0.280 24.0 1.116 0.347 1.885 T1DM UCB
 Tong et al., 2013 3 0.320 0.210 3 0.525 0.130 10.9 − 0.937 − 2.622 0.749 T2DM UCB
  1. aFasting C-peptide
  2. bStimulated peak C-peptide
  3. *Measuring unit; pmol/L
  4. #Measuring unit; IU/day