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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Microenvironmental changes induced by placenta-derived mesenchymal stem cells restore ovarian function in ovariectomized rats via activation of the PI3K-FOXO3 pathway

Fig. 2

The number of follicles in the ovaries of rats depends on the engraftment of PD-MSCs. a The expression of the human Alu gene in ovary tissues of ovariectomized rats at 1, 2, 3, and 5 weeks after PD-MSC transplantation was analyzed by quantitative real-time polymerase chain reaction analysis, normalized to GAPDH as an internal control (mean ± SE) (n = 5 per group). b Histological staining of the ovaries in ovariectomized rats at 1, 2, 3, and 5 weeks after injection of PD-MSCs was performed with hematoxylin and eosin staining. Scale bars = 50 μm. c The number of follicles ≤ 100 μm in the ovary was counted (mean ± SE) (n = 3 per group). Significance at p < .05 is indicated by an asterisk (*) for NTx vs. others and a number sign (#) for DTx vs. TTx

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