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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Microenvironmental changes induced by placenta-derived mesenchymal stem cells restore ovarian function in ovariectomized rats via activation of the PI3K-FOXO3 pathway

Fig. 7

Summary of the ability of PD-MSCs to restore ovary function in the ovariectomized model. PD-MSCs promote folliculogenesis in the ovary, as indicated by the upregulation of pathway markers, including Nanos3, Nobox, LHX8, and Lin28a. Additionally, SCF expressed in PD-MSCs dramatically increased pGSK3β, which is involved in oocyte growth, and decreased oocyte apoptosis by inducing pFOXO3a expression via the PI3K-pAkt pathway

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