Fig. 3

3D culture enhanced function maturation of INS-producing cells. a Representative images of PECs-2D and PECs-3D stained with dithizone. Scale bars, 50 μm. b Secreted C-peptide in response to high (20 mM) concentrations of d-glucose (Glu), 30 mM potassium chloride (KCl), or 30 μM Forskolin (FSK) was measured with a C-peptide ELISA kit. Data represent mean ± SD (n = 3), **p < 0.01,***p < 0.001