Fig. 1
Experimental design, glucose levels and body weight. a Diagrammatic representation of an experimental scheme. Pain killer (PK) tramadol (0.2 per mg mouse a day) was administered in drinking water for four consecutive days (− 1, 0, 1 and 2 day). At 0-day mice were anaesthetized and Px was performed. Once Px was completed, 0.5 × 106 hTERT-MSC were transplanted by intravenous route (IVR) or intrapancreatic route (IPR) on 0 days. Controls were pancreatectomized and injected with cell culture medium intravenously, n = 10. b Mice were evaluated daily for well-being (scoring sheet, refer supplement 1). IPR group revived faster from pancreatic insult than others, n = 10. c Percentage survival of mice following Px was similar in the three groups during the observation window of 8 days, n = 14. d Blood glucose levels were measured 8 days after Px and showed the lowest concentrations in IPR compared to other groups without significance, n = 10. e Body weights were measured daily, n = 10. Profiles were similar in the three Px groups and showed recovery to initial body weight after 8 days in the experimental groups, but not in the control group. Human telomerase reverse transcriptase mesenchymal stem cells (hTERT-MSC). Data are given as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001