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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway

Fig. 4

hTERT-MSC stimulated growth factors and anti-inflammatory markers in the residual pancreas. a EGF protein was evaluated 8 days after pancreatectomy and MSC administration. Route dependent increase in EGF protein was analyzed by Western blot, n = 3. Panel b demonstrates that EGF transcripts were accordingly increased, n = 4. c Expression of IFN-γ and TNF-α genes in the residual pancreas. MSC transplantation reduced IFN-γ and TNF-α transcript levels in both IVR and IPR groups as compared to control, n = 4. d Gene expressions of GLUT-2 and Ins2 were enhanced in IPR-injected mice compared to controls and IVR-transplanted mice. Ins1 gene expression increased in IPR, but not in IVR-treated mice compared to control, n = 4. Epidermal growth factor (EGF), glucose transporter 2 (GLUT-2), preproinsulin 1 (Ins1), preproinsulin 2 (Ins2), interferon gamma (IFN-γ), tumour necrosis factor alpha (TNF-α), intravenous route (IVR), intrapancreatic route (IPR) and human telomerase reverse transcriptase mesenchymal stem cells (hTERT-MSC). Data are given as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, post hoc test versus sham-operated control group

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