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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway

Fig. 5

hTERT-MSC activated factors specific for endocrine pancreatic progenitor cells. In each of the panels ac, the two upper images represent the expression of the protein and the lower image fold expression of gene normalized to the control (Px only group). a Represents the increase of phosphorylated AKT protein expression in MSC-infused pancreas (upper and middle panels) and concomitant augmentation of the quantity of PI3K and AKT transcripts (lower panel). Significant differences were observed between IPR and control (p < 0.03) at the protein level and all experimental groups at the mRNA level. b Demonstrates the enhancement of forkhead box protein A2 (FOXA2) concentration in IVR and IPR MSC-treated groups. c Pancreatic and duodenal homeobox 1 (PDX-1) showed a significant augmentation between control and IPR by Western blot (p < 0.02) and RT-PCR (p < 0.017). Intravenous route (IVR), intrapancreatic route (IPR), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), protein kinase B (AKT), human telomerase reverse transcriptase mesenchymal stem cells (hTERT-MSC) and beta-tubulin band are similar in Figs. 4 and 5 (same membrane). Data are given as mean ± SEM. n = 3, *p < 0.05, **p < 0.01, ***p < 0.001, comparisons performed with the control

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