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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway

Fig. 6

hTERT-MSC downregulated FoxO1 to regenerate β-cells. a After 8 days of MSC infusion in partially pancreatectomized mice, MSC route-dependent downregulation of forkhead box protein 1 (FoxO1) protein was monitored. FoxO1 expression was significantly reduced in IPR and IVR compared to control on protein (b) and gene (c) level. d Immunohistochemistry was performed to investigate FoxO1 straining within the pancreatic islets and representative sections are shown. Compared with control FoxO1 staining was decreased in IVR and IPR group. Intravenous route (IVR), intrapancreatic route (IPR) and human telomerase reverse transcriptase mesenchymal stem cells (hTERT-MSC). Data represent the mean ± SEM. n = 3, *p < 0.05, **p < 0.01, ***p < 0.001, statistical comparisons were performed with the control

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