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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Comparison of reversal of rat pulmonary fibrosis of nintedanib, pirfenidone, and human umbilical mesenchymal stem cells from Wharton’s jelly

Fig. 3

Comparison of the left lung alveolar space in rats with PF. The MRI of rats’ thoracic cavities from the level of the trachea carina is displayed. L indicates the left lung, and R indicates the right lung (a). The carina was set as a landmark for image positioning. In addition to the slice containing the carina, two images before and after the carina were collected. These five images were summed for the quantification of the black alveolar space to represent the left-lung alveolar volume of each rat. The results showed that the alveolar volume significantly reduced after BLM damage. Transplantation of HUMSCs effectively increased the alveolar volume. In other treatment groups, the alveolar volume significantly decreased on day 7 after BLM damage, and no improvements were seen until day 49 (b). n = 4 or 5 in each group. : vs the Normal group, p < 0.05. #: vs the BLM group, p < 0.05

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