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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages

Fig. 4

ABs derived from MSCs promoted cutaneous wound healing. a The schematic graph shows the protocol of establishment and treatment for mouse skin wound models. b Representative photographs of cutaneous wounds in different groups at different time points during the wound healing procedure. c Quantification of the wound healing rate. d Quantification of the body weight. e Representative images of the H&E staining of the skin samples. Scale bar,1 mm in low-magnification images, 500 μm in high-magnification images. f Representative images of the Masson staining of the skin samples. Scale bar, 1 mm in low-magnification images, 500 μm in high-magnification images. g Representative images and quantification of the cytokeratin 14 expression in the skin tissue. Scale bar, 100 μm. h Immunofluorescence staining shows ABs engulfed by F4/80-positive macrophages in vivo. Scale bar, 20 μm. i Representative images and quantification of the CD206 expression in the skin tissue. Scale bar, 50 μm. n = 6 per group. Data shown as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001; NS, not significant. PBS, phosphate-buffered saline; Gel, PF-127 gel; Gel+ABs, ABs embedded in PF-127 gel; ABsPKH26, ABs labeled with PKH26

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