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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells

Fig. 4

Paracrine effect of ADSCs against histone-mediated cytotoxicity with HUVECs. a The relative cell viability of HUVECs after co-culture with or without ADSCs-DMSO or ADSCs-GW4869 exposed to histones (100 μg/mL) for 4 h. N = 6 in each group. **p < 0.01 vs. control, p < 0.05 vs. histones. bd Representative immunoblots and densitometric analysis of phosphorylated Akt and cleaved caspase-3 in HUVECs 4 h after histone challenge with or without ADSCs-DMSO and ADSCs-GW4869. N = 4 in each group. *p < 0.05 vs. control, p < 0.05 vs. histones, p < 0.05 vs. histones+ADSCs-DMSO

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