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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells

Fig. 5

Inhibition of LY294002 and GW4869 on the protective effect of ADSCs in mice. a, b Representative immunoblots and densitometric analysis of phosphorylated Akt in lung tissue 6 h after histone challenge with or without ADSCs, ADSCs-GW4869, and LY294002. N = 5 in each group. **p < 0.01 vs. control group, p < 0.05 vs. ADSCs+histones group. c Kaplan-Meier survival curves showing survival in the saline+histones group, the ADSCs+histones group, the GW4869 ADSCs+histones group, and the LY294002 + ADSCs+histones group. N = 8 in each group. d In vivo pulmonary vascular permeability assay measured by Evans Blue dye. N = 5 in each group. **p < 0.01 vs. control group, p < 0.05 vs. saline+histones group, ††p < 0.01 vs. saline+histones group, ‡‡p < 0.01 vs. ADSCs+histones group. e Representative photomicrographs of lung sections with H&E staining 6 h after injections of ADSCs or ADSCs-GW4869 and histones with or without LY294002. Scale Bar, 50 μm

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