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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells

Fig. 6

Inhibition of miR-126 on the protective effect of ADSCs against histone-mediated cytotoxicity with HUVECs. a, b The expression of miR-126 in ADSCs and exosomes before or after 2 h of exposure to histones was evaluated using RT-PCR. N = 3 in each group. *p < 0.05, **p < 0.01 vs. control group. c The relative cell viability of histone-exposed HUVECs (100 μg/mL, 4 h) after co-culture with ADSCs, miR-126 mimics ADSCs or miR-126 inhibitor ADSCs. N = 3 in each group. **p < 0.01 vs. control, ††p < 0.01 vs. miR-126 mimic, p < 0.05 vs. control. df Immunoblot results of phosphorylated Akt and cleaved capsase-3 in histone-exposed HUVECs (100 μg/mL, 4 h) co-cultured with ADSCs, miR-126 mimic ADSCs or miR-126 inhibitor ADSCs. N = 4~6 in each group. *p < 0.05, **p < 0.01 vs. control, ††p < 0.01 vs. miR-126 mimic

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