Fig. 6

Inhibition of miR-126 on the protective effect of ADSCs against histone-mediated cytotoxicity with HUVECs. a, b The expression of miR-126 in ADSCs and exosomes before or after 2 h of exposure to histones was evaluated using RT-PCR. N = 3 in each group. ^*p < 0.05, ^**p < 0.01 vs. control group. c The relative cell viability of histone-exposed HUVECs (100 μg/mL, 4 h) after co-culture with ADSCs, miR-126 mimics ADSCs or miR-126 inhibitor ADSCs. N = 3 in each group. ^**p < 0.01 vs. control, ^††p < 0.01 vs. miR-126 mimic, ^‡p < 0.05 vs. control. d–f Immunoblot results of phosphorylated Akt and cleaved capsase-3 in histone-exposed HUVECs (100 μg/mL, 4 h) co-cultured with ADSCs, miR-126 mimic ADSCs or miR-126 inhibitor ADSCs. N = 4~6 in each group. ^*p < 0.05, ^**p < 0.01 vs. control, ^††p < 0.01 vs. miR-126 mimic