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Table 2 Comparison of previously published ES-Sac and the current serum/feeder-free differentiation protocols

From: Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

 

Relative cost of differentiation protocols

RBC differentiation time (Days)

Enucleation rate in RBCs

β-globin protein expression in RBCs

ES-Sac (Previous feeder-dependent methods) [12, 14]

$$

32

1.40%

4%

Serum/feeder-free organoid differentiation method

$$$

32

8%

14.5%

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Stem Cell Research & Therapy

ISSN: 1757-6512