Groupa | Group A (n = 22) | Group B (n = 24) | Group C (n = 20) | Group D (n = 22) |
---|---|---|---|---|
Demographics | ||||
Sex, no. % male | 10 (45.5%) | 11 (45.8%) | 10 (50.0%) | 15 (68.2%) |
Age, year; mean (SD; range)b | 3.0 (1.2; 1.5–6.3) | 2.9 (1.3; 1.0–5.0) | 3.4 (1.3; 1.1–5.8) | 3.0 (1.1; 1.2–6.0) |
Gestational age, weeks; mean (SD; range) | 32.3 (4.8; 26–41) | 31.9 (3.9; 26–40) | 31.9 (4.3; 26–40) | 33.6 (5.4; 24–42) |
Preterm, no. (%) | 16 (72.7%) | 20 (83.3%) | 16 (80.0%) | 13 (59.1%) |
Birth weight (SD; range), kg | 1.9 (.8; .6–3.6) | 1.9 (.8; .8–3.4) | 1.9 (.8; .7–3.5) | 2.2 (.9; .7–4.2) |
NBW/LBW/VLBW/ELBWc | 6/7/8/1 | 5/10/7/2 | 5/8/5/2 | 10/7/3/2 |
GMFCS (I/II/III/IV/V) | 1/2/5/6/8 | 2/2/5/3/12 | 1/6/3/7/3 | 0/1/5/10/6 |
Typology (SB/SU/D/C/A)d | 18/0/3/0/1 | 20/0/4/0/0 | 15/0/4/0/1 | 17/0/4/0/1 |
Baseline primary outcome measures | ||||
GMFM | 38.0 (22.9) | 31.9 (24.4) | 44.3 (21.8) | 31.1 (16.2) |
GMPM | 34.1 (14.7) | 32.7 (13.6) | 38.1 (11.5) | 35.9 (11.2) |
BSID-II mental raw score | 106.4 (38.5) | 99.2 (44.1) | 121.7 (33.2) | 100.9 (39.1) |
BSID-II motor raw score | 49.8 (19.9) | 48.3 (24.5) | 61.1 (20.1) | 47.5 (21.5) |
MRI finding s[49] | ||||
Normal (n = 0) | 0 | 0 | 0 | 0 |
Acquired lesions (n = 87) | ||||
Periventricular leukomalacia (n = 66) | 17 | 20 | 14 | 15 |
Diffuse encephalopathy (n = 18) | 4 | 4 | 5 | 5 |
Focal ischemia/hemorrhage (n = 1) | 0 | 0 | 0 | 1 |
Multicystic encephalomalacia (n = 2) | 1 | 0 | 0 | 1 |
Malformations (n = 0) | ||||
Cortical dysplasia (n = 0) | 0 | 0 | 0 | 0 |
Schizencephaly (n = 0) | 0 | 0 | 0 | 0 |
Corpus callosum agenesis (n = 0) | 0 | 0 | 0 | 0 |
Miscellaneous/unknown (n = 1) | ||||
Miscellaneous etiologies (n = 0) | 0 | 0 | 0 | 0 |
Abnormality of white matter signal (n = 1) | 0 | 0 | 1 | 0 |