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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1

Fig. 6

miR-218 reduces expression of hypertrophy-related markers during chondrogenesis of MSC. MSC (N = 4–5 donors) were transfected with miR-218 (gray), or with a control non-targeting miR (NC, black) mimic at day 0 and subjected to chondrogenic differentiation for 28 days; mRNA expression for indicated genes was monitored at indicated time points by qRT-PCR. Levels of mRNA expression were normalized to a geomean of HPRT, CPSF6, and RPL13; mean values ± SD are shown; *p ≤ 0.05, **p ≤ 0.01; NC vs miR281; two-tailed t test

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Stem Cell Research & Therapy

ISSN: 1757-6512