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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1

Fig. 9

A scheme depicting a putative mechanism for the anti-hypertrophic effects caused by miR-218 in MSC and activation of a feedback loop due to concomitant effects on inhibitors of WNT/β-catenin signaling. MiR-218 targets hypertrophy-related mRNAs: MEF2C and its downstream targets, COL10A1 and IBSP, leading to attenuation of the hypertrophic phenotype. Among the other targets of miR-218, there is RUNX2, a transcription factor regulating expression of COL10A1 and ALPL. However, accumulation of β-catenin due to concomitant targeting of WNT signaling inhibitors activates a feedback loop that counteracts the anti-hypertrophic alterations. Arrows indicate directions of expression regulation: red—downregulation, green—upregulation

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Stem Cell Research & Therapy

ISSN: 1757-6512