Fig. 4

miR-29b-1-5p is downregulated during endometrium repair by WJ-MSCs. a The differences in miRNA expression profiles between the two groups by a miRNA microarray analysis are presented in the form of a heat map. N1–3, non-cocultured WJ-MSCs; T1–3, cocultured WJ-MSCs. Each group consisted of three individuals. miRNAs are represented by single rows and samples by single columns. b Volcano plot of miRNA microarray analysis data. The values on the X- and Y-axes represent normalized fold changes and P values, respectively. The color scale indicates relative expression, upregulation (red) and downregulation (green). miRNAs with fold change > 2 and P ≤ 0.05 were regarded as differentially expressed. c Circos plot shows the most significantly upregulated (red) and downregulated (green) miRNA expression profiles in the entire genome. d miR-29b-1-5p expression in WJ-MSCs cocultured with or without damaged ESCs by qRT-PCR. N, non-cocultured WJ-MSCs; T, cocultured WJ-MSCs. Data in panel are shown as means ± standard deviation (n = 3). ^**P < 0.001. e The complementary pairing sequence between 3′UTR of RAP1B and miR-29b-1-5p