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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Paracrine stimulation of perinatal lung functional and structural maturation by mesenchymal stem cells

Fig. 1

MSC-CM increased activity and mRNA expression of Na+ transporters in FDLE cells. FDLE cells were subjected to MSC-CM or control medium for 24 h. Statistical differences between the two groups were analyzed with a t test. a–c Data are displayed as boxes and whiskers with the 10–90 percentiles, mean (+) and median (horizontal line). a MSC-CM significantly enhanced Ibase and ∆Iamil in FDLE cells (n = 78–82, 4 independent experiments (IE); ***p < 0.001). b Maximal ENaC activity (amilmax) was significantly higher in FDLE cells cultured in MSC-CM (n = 26–27, 3 IE; **p < 0.01). c Maximal Na,K-ATPase activity (ouabmax) was higher in FDLE cells treated with MSC-CM (n = 42–46, 2 IE; ***p < 0.001). d, e Data are displayed as mean + SEM. d mRNA expression of ENaC subunits (ENaCα, ENaCβ, ENaCγ) and Na,K-ATPase subunits (Na,K-ATPase α1 & Na,K-ATPase β1) were increased by MSC-CM (n = 6–8, 2 IE; *p < 0.05; **p < 0.01; ***p < 0.001). e Surfactant protein A1, B, C (Sftpa1, Sftpb, Sftpc) mRNA levels were elevated by MSC-CM (n = 3; *p < 0.05; ***p < 0.001). □ control, ■ MSC-CM

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