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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Enhanced PRL-1 expression in placenta-derived mesenchymal stem cells accelerates hepatic function via mitochondrial dynamics in a cirrhotic rat model

Fig. 6

PD-MSCsPRL-1 using a nonviral system enhances hepatic function by regulating mitochondrial metabolism in a rat BDL model. a Western blotting of albumin and human PRL-1 gene expression by PD-MSCPRL-1 transplantation in pooled BDL-injured rat liver tissue (n = 5). b mRNA expression of albumin in a rat model with pooled BDL liver tissue (n = 5). Protein expression of the c Rho family (ROCK1 and RhoA), cell cycle (CDK4 and Cyclin D1), and mitochondrial metabolism (PDH, SDHA, ATP5B, and PHB1) by PD-MSCPRL-1 transplantation in pooled BDL-injured rat liver tissue (n = 5). e mtDNA copy number in BDL-injured rat liver tissue by the TaqMan assay. Rat nuclear DNA was used as an internal control. f ATP production assay in rat BDL liver lysate (10 μg/μl). Data from each group are presented as the mean ± SD. *p < 0.05 versus NTx group; #p < 0.05 versus TTx naïve group. CDK4; cyclin-dependent kinase 4, Con, control group; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; NTx, nontransplantation group; PDH, pyruvate dehydrogenase; PHB1, prohibitin 1; PRL-1, phosphatase of regenerating liver-1; SDHA, succinate dehydrogenase; TTx, transplantation group

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