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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting odontogenesis

Fig. 6

DPSCs-sEV-stimulated macrophage-conditioned medium enhances odontogenic differentiation in DPSCs via BMP signaling. a DPSCs-sEV-stimulated macrophage-conditioned medium upregulated DSP and DMP-1 proteins and b enhanced calcium deposition and nodule formation in DPSCs. c DPSCs-sEV-stimulated macrophage-conditioned medium increased the protein expression amounts of BMPR1, p-SMAD1/5/9, and SMAD4 in DPSCs, without altering TGFR1 and p-SMAD2/3 levels

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