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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting odontogenesis

Fig. 7

DPSCs-sEV polarize macrophages toward the pro-healing M2 phenotype that promotes odontogenesis in vivo. a The amounts of CD163-immunopositive M2 macrophages were remarkably increased in dental pulp tissue treated with DPSCs-sEV, while fewer CD11c-immunopositive M1 macrophages were observed, compared with the control group. The odontoblast-specific markers DSP (b) and DMP-1 (c) were significantly upregulated in dental pulp tissue incubated with DPSCs-sEV, compared with the control group

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Stem Cell Research & Therapy

ISSN: 1757-6512