Fig. 6

Primary colonies derived from transductants exposed to AA/RA exhibit few differentially expressed genes compared to DMOG/AA/RA colonies. a Hierarchical cluster analysis to identify subsets of genes that show specific expression patterns across specific samples of canine fetal fibroblasts (cFF; labeled 0 DPI), maturing (10 DPI) canine reprogramming intermediates, and cESC. Divergent color scale represents gene expression scaled by row. b Relative abundances of transcripts associated with cell pluripotency. c Relative abundances of transcripts associated with early embryonic (naïve) pluripotency. d Relative abundances of transcripts associated with cell surface proteins or the synthesis of cell surface antigens. e Relative abundances of transcripts associated with leukemia inhibitory factor (LIF)-signal transducer and activator of transcription 3 (STAT3) signaling. f Relative abundances of transcripts associated with chromatin-modifying or remodeling enzymes involved in the activation of gene transcription. g Relative abundances of transcripts associated with chromatin-modifying or remodeling enzymes involved in the repression of gene transcription. Data are presented as mean ± standard error, n = 3. Means annotated with different letters are considered significantly different by one-way analysis of variance and Tukey’s honestly squared difference test, P < 0.05