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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Allogeneic human umbilical cord Wharton’s jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo

Fig. 3

Culture of UCB CD34+ cells with hWJSC-CM and hWJSCs. A (a–c) Low-magnification phase-contrast images of CD34+ cells growing in the presence of hWJSCs and hWJSC-CM against controls. Note the larger numbers of CD34+ cells in hWJSCs and hWJSC-CM compared to controls. (d–f) High magnification insets showing pseudopodia-like outgrowths in CD34+ cells expanded in hWJSC-CM (e) and attachment of CD34+ cells to hWJSCs in (f). B Note greater total cell numbers of CD34+ cells expanded with hWJSCs and hWJSC-CM as compared to controls (statistically significant between hWJSC-CM and controls). (C) Note significant increases in fold changes of CD34+ cell numbers after expansion with hWJSCs and hWJSC-CM compared to controls. All values are expressed as mean ± SEM of 3 biological samples with 3 replicates for each sample. *p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512