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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis

Fig. 3

The distribution of GDNF-AMSCs in the injured kidney and GDNF-AMSCs inhibits EndMT progression in the obstructed kidney. a Intravenously delivered GFP-labeled AMSCs (green) were detected in the obstructed kidneys at days 3 and 7, and GFP-labeled GDNF-AMSCs (green) were more detected by laser confocal microscopy. Nuclei were stained with DAPI (blue). b There was no evident two-color immunofluorescence that identifies EndMT cells that coexpress endothelial cells (CD31, red) and myofibroblast cells (a-SMA, green) shown in the sham group. EndMT progression was increased in the UUO group and decreased in the AMSC and GDNF-AMSC group, especially in the GDNF-AMSC group, indicating by the coexpression of CD31+a-SMA+. White arrows indicate positive coexpressing staining. Nuclei were stained with DAPI in blue. Bar = 20 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512