Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis

Fig. 7

Western blot analysis of p-eNOS, eNOS, PI3K, p-Akt, Akt, HIF-1α, gp91-phox, and p67-phox and comparisons of HIF-1α, gp91-phox, and p67-phox mRNA expressions in each group by qRT-PCR. Representative Western blots (a) and quantitative data (bd) are presented (*P < 0.05, **P < 0.01, ***P < 0.001). Blockade of PI3K/AKT/eNOS pathway abolished GDNF stimulation of Akt and eNOS phosphorylation. HIF-1α, gp91-phox, and p67-phox expression was confirmed after GDNF-AMSC treatment. Representative Western blot (e) and quantitative data for HIF-1α, gp91-phox, and p67-phox (f) are presented, and HIF-1α, gp91-phox, and p67-phox mRNA levels were shown by real-time PCR (g) (*P < 0.05, **P < 0.01, ***P < 0.001)

Back to article page