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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Endothelial progenitor cells promote osteogenic differentiation in co-cultured with mesenchymal stem cells via the MAPK-dependent pathway

Fig. 3

PCR array analysis of co-cultured MSCs, monolayer culture MSCs were used as control. a Heat map displaying hierarchical clustering of differentially expressed genes from co-cultured MSCs. Upregulated genes are shown in red, whereas downregulated genes are shown in green. b Volcano plot of microarray data. The horizontal bar represents the nominal significant level of 0.01 for Student’s t tests, the vertical dashed bars denote ≤ 0.6-fold downregulation (left) or ≥ 0.6-fold upregulation (right). c KEGG enrichment analyses of targeted genes indicated that the effects of EPCs on the regulation of MSCs are associated with MAPK signaling pathway, ECM-receptor interaction, TNF signaling pathway, PI3K-Akt signaling pathway, HIF-1 and Ras signaling pathway, and so on

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