Fig. 3

Gene set enrichment analysis (GSEA). Chord diagrams of top 5 upregulated and downregulated gene ontology (GO) terms (functional database: biological processes) found in a MSC “healthy” secretome gene set enrichment analysis; b MSC “traumatic” secretome gene set enrichment analysis; c MSC “degenerative” secretome gene set enrichment analysis; d MSC “IL-1β” secretome gene set enrichment analysis (LC-MS/MS data). All reported GO terms (right hemisphere) were significantly up- or downregulated (P < 0.01). Gene-box color (left hemisphere) indicates detection level as log2 fold change relative to the baseline control: upregulated detection = red, downregulated = blue. Strings indicate involvement of each gene in all respective GO-terms