Table 1 Proteins identified in secretomes of mesenchymal stromal cells stimulated with healthy, traumatic, or degenerative intervertebral disc conditioned medium or IL1-β, with a log2 fold-change > 1.5 (relative to the baseline control stimulation)
gene_ID | protein_ID | Medium stimulus |
|---|---|---|
CHAD | O15335 | Healthy, Traumatic, Degenerative |
CILP | O75339 | Healthy, Traumatic, Degenerative |
FGA | P02671 | Healthy, Traumatic, Degenerative |
FGB | P02675 | Healthy, Traumatic, Degenerative |
DCN | P07585 | Healthy, Traumatic, Degenerative |
CTSB | P07858 | Healthy, Traumatic, Degenerative |
VCAN | P13611 | Healthy, Traumatic, Degenerative |
ACAN | P16112 | Healthy, Traumatic, Degenerative |
LAMA1 | P25391 | Healthy, Traumatic, Degenerative |
COMP | P49747 | Healthy, Traumatic, Degenerative |
PRG4 | Q92954 | Healthy, Traumatic, Degenerative |
IGHA1 | P01876 | Healthy, Degenerative, IL-1β |
ABI3BP | Q7Z7G0 | Healthy, Degenerative, IL-1β |
STC2 | O76061 | Traumatic, Degenerative, IL-1β |
SERPINA1 | P01009 | Traumatic, Degenerative, IL-1β |
MMP1 | P03956 | Traumatic, Degenerative, IL-1β |
SRGN | P10124 | Traumatic, Degenerative, IL-1β |
MAN1A1 | P33908 | Traumatic, Degenerative, IL-1β |
CXCL12 | P48061 | Traumatic, Degenerative, L-1β |
B2M | P61769 | Traumatic, Degenerative, IL-1β |
FNDC1 | Q4ZHG4 | Traumatic, Degenerative, IL-1β |
SRPX2 | O60687 | Traumatic, Degenerative |
SEMA7A | O75326 | Traumatic, Degenerative |
TIMP1 | P01033 | Traumatic, Degenerative |
FGG | P02679 | Traumatic, Degenerative |
ALB | P02768 | Traumatic, Degenerative |
SERPINE2 | P07093 | Traumatic, Degenerative |
CLU | P10909 | Traumatic, Degenerative |
CDH2 | P19022 | Traumatic, Degenerative |
LUM | P51884 | Traumatic, Degenerative |
SRPX | P78539 | Traumatic, Degenerative |
COL7A1 | Q02388 | Traumatic, Degenerative |
SPOCK1 | Q08629 | Traumatic, Degenerative |
LTBP1 | Q14766 | Traumatic, Degenerative |
TGFBI | Q15582 | Traumatic, Degenerative |
SBSN | Q6UWP8 | Traumatic, Degenerative |
FAM3C | Q92520 | Traumatic, Degenerative |
PXDN | Q92626 | Traumatic, Degenerative |
HTRA1 | Q92743 | Traumatic, Degenerative |
CTHRC1 | Q96CG8 | Traumatic, Degenerative |
HAPLN1 | P10915 | Healthy |
BPIFB1 | Q8TDL5 | Healthy |
APOA1 | P02647 | Healthy |
COL4A1 | P02462 | Healthy |
COL11A1 | P12107 | Healthy |
MUC5B | Q9HC84 | Healthy |
IGKC | P01834 | Healthy |
APOD | P05090 | Healthy |
IGHG1 | P01857 | Healthy |
APCS | P02743 | Healthy |
IGLL5 | B9A064 | Healthy |
ADAMTS2 | O95450 | Healthy |
ULBP2 | Q9BZM5 | Healthy |
OGN | P20774 | Healthy |
EFEMP1 | Q12805 | Healthy |
IGFBP6 | P24592 | Healthy |
OLFML3 | Q9NRN5 | Healthy |
A2M | P01023 | Healthy |
LOXL2 | Q9Y4K0 | Healthy |
NEGR1 | Q7Z3B1 | Healthy |
SDF4 | Q9BRK5 | Healthy |
BMP1 | P13497 | Healthy |
CST3 | P01034 | Healthy |
MMP14 | P50281 | Healthy |
FBN1 | P35555 | Traumatic |
GALNT1 | Q10472 | Traumatic |
CCDC80 | Q76M96 | Traumatic |
LTBP2 | Q14767 | Traumatic |
HPX | P02790 | Degenerative |
ITIH1 | P19827 | Degenerative |
LGALS7; LGALS7B | P47929 | Degenerative |
CLSTN1 | O94985 | Degenerative |
SMOC1 | Q9H4F8 | Degenerative |
ENO3 | P13929 | Degenerative |
VASN | Q6EMK4 | Degenerative |
KRT16 | P08779 | Degenerative |
CFB | P00751 | IL1-β |
IL6 | P05231 | IL1-β |
C3 | P01024 | IL1-β |
MMP10 | P09238 | IL1-β |
MYH7 | P12883 | IL1-β |
ALDH1A1 | P00352 | IL1-β |
LBP | P18428 | IL1-β |
FABP1 | P07148 | IL1-β |
CHI3L1 | P36222 | IL1-β |
VCAM1 | P19320 | IL1-β |
CHI3L2 | Q15782 | IL1-β |
TNC | P24821 | IL1-β |