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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: ELABELA ameliorates hypoxic/ischemic-induced bone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways

Fig. 4

ELA treatment ameliorated H/I-induced mitochondrial dysfunction in MSCs. a Representative confocal images of JC-1 staining. Scale bar = 100 μm. b Quantitative analysis of mitochondrial membrane potential with JC-1 staining. c ATP content was evaluated using a luminescence enzymatic assay. The ATP level in each group was expressed as the bioluminescence intensity that was normalized to the control group (N = 3). *P < 0.05. ELA, ELABELA; MSC, mesenchymal stem cell; H/I, hypoxic/ischemic; ATP, adenosine triphosphate

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Stem Cell Research & Therapy

ISSN: 1757-6512