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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: ELABELA ameliorates hypoxic/ischemic-induced bone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways

Fig. 6

ELA activated the ERK1/2 signaling pathway in reducing the apoptosis of MSCs caused by H/I condition. Representative immunoblots and quantitative data were provided. a t-ERK1/2 and p-ERK1/2 expression in separate groups. b Utilization of U0126 further verified the role of ELA in activating ERK1/2 phosphorylation (N = 3). *P < 0.05. ELA, ELABELA; MSC, mesenchymal stem cell; H/I, hypoxic/ischemic; t-ERK1/2, total ERK1/2; p-ERK1/2, phosphorylated ERK1/2

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