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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6

Fig. 7

hucMSC-Exo were enriched with miR-27b-3p that could suppress the EMT process. a qRT-PCR showed that the application of antagomiR-27b-3p could counteract the overexpression of miR-27b-3p caused by hucMSC-Exo. b Western blot analysis indicated that antagomiR-27b-3p could recover the EMT process suppressed by hucMSC-Exo. c Effect of antagomiR-27b-3p on the EMT-related protein changes assessed by immunofluorescence. d–e Effects of antagomiR-27b-3p on the migration and wound-healing ability of ARPE19 cells were measured by Transwell and scratch assays; hucMSC-Exo was used as a reference. Statistics are presented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512