Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

Fig. 4

MSC-derived PGE2 inhibits NLRP3 inflammasome activation via TAK1. a The protein expression levels of NLRP3 inflammasome and TAK1 signaling in BMDM following indicated condition. b The levels of IL-1β in each supernatant (n = 3). c The protein expression levels of NLRP3 inflammasome and TAK1 signaling in BMDM treated with exogenous PGE2. d The levels of IL-1β in cell supernatant treated with exogenous PGE2 (n = 3). e Effects of TAK1 inhibitor, 5Z-7-ox (TAKi), on NLRP3 inflammasome activation in BMDM. f The levels of IL-1β in cell supernatant treated with TAKi (n = 3). g Expression of NLRP3 inflammasome signaling in the liver pretreated with TAKi. h Measurement of caspase-1 enzymatic activity in the liver of each group (n = 4). i Serum levels of IL-1β in each group (n = 4) (*p < 0.05, **p < 0.01)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512