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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

Fig. 6

MSC-derived PGE2 promotes M2 macrophage through STAT6 and mTOR signaling. a Protein levels of STAT6 and mTOR signaling in BMDM following indicated condition. b Protein levels of mTOR signaling in BMDM treated with mTOR inhibitor (rapamycin, Rap) and AKT inhibitor (MK-2206) following indicated condition. c The mRNA levels of M2 markers (Arg1, Mgl1, Mgl2, and Ym1) in BMDM treated with Rap following indicated condition (n = 3). d The mRNA levels of M2 markers (Arg1, Mgl1, Mgl2, and Ym1) in BMDM treated with MK-2206 following indicated condition (n = 3) (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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Stem Cell Research & Therapy

ISSN: 1757-6512