Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

Fig. 7

MSC-derived PGE2 protects against liver inflammation via EP4. a The mRNA levels of inflammatory cytokines (IL-1β, CCL2, iNOS, TNF-α) in the liver from each group pretreated with EP4 inhibitor (EP4i) (n = 4). b The protein expression levels of NF-κB signaling in each group pretreated with EP4i. c The protein expression levels of TAK1 signaling in each group pretreated with EP4i. d The protein expression levels of NLRP3 inflammasome signaling in each group pretreated with EP4i. e Measurement of caspase-1 enzymatic activity in the liver of each group pretreated with EP4i (n = 4). f Protein levels of NLRP3 inflammasome and TAK1 signaling in BMDM pretreated with EP4i or knocking down of EP4 via siRNA. g The levels of IL-1β in supernatants of BMDM pretreated with EP4i or knocking down of EP4 via siRNA (*p < 0.05, **p < 0.01)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512