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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Glucocorticoid guides mobilization of bone marrow stem/progenitor cells via FPR and CXCR4 coupling

Fig. 1

Glucocorticoid treatment promoted the chemotaxis of bone marrow-derived stem/progenitor cell subsets via glucocorticoid receptor. a GC promoted MSC chemotaxis toward fMLP. *P < 0.05, **P < 0.01 vs. the control group, # #P < 0.01 vs. the fMLP group, @@P < 0.01 vs. the fMLP + 75 ng/ml GC group and the fMLP + 100 ng/ml GC group. b GC promoted EPC chemotaxis toward fMLP. **P < 0.01 vs. the control group, #P < 0.05, # #P < 0.01 vs. the fMLP group, @P < 0.05 vs. the fMLP + 100 ng/ml GC group. c GC could not promote MSC directional migration through transwell membrane within 3 h. d GC could not promote EPC directional migration through transwell membrane within 3 h. e RU486 inhibited GC-induced MSC chemotaxis toward fMLP. *P < 0.05, **P < 0.01 vs. the control group; #P < 0.05 vs. the fMLP group, @P < 0.05 vs. the fMLP + 75 ng/ml GC group. f RU486 inhibited GC-induced EPC chemotaxis toward fMLP. *P < 0.05, **P < 0.01 vs. the control group, #P < 0.05 vs. the fMLP group, @P < 0.05 vs. the fMLP + 75 ng/ml GC group. MSCs, mesenchymal stem cells; EPCs, endothelial progenitor cells; GC, glucocorticoid; fMLP, N-formyl methionyl leucyl phenylalanine. Data are mean ± SD of six representative observations

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