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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys

Fig. 2

Mobilization of murine HPCs by HF51116. a, b The dose-dependent response of HF51116 in C3H/HEJ mice. HF51116 was given at different doses and AMD3100 was given at 5 mg/kg. The negative control group received saline only. Blood samples were collected at 1 h post-injection. a Sum of CFUs at different doses. b Composition of CFUs at different doses (mean ± SEM of n = 12 mice/group/dose). c, d Dynamic change of efficacy at different times following subcutaneous (s.c.) injections of HF51116 (5 mg/kg) or AMD3100 (5 mg/kg) into C3H/HEJ mice. HF51116 and AMD3100 were given at the same dose. CFU numbers were measured at different times for HF51116 and at 1 h for AMD3100. c Sum of CFUs at different times. d Composition of CFUs at different times (mean ± SEM of n = 10 mice/time point, n = 9 mice for 4 h, n = 12 mice for the AMD3100 group). e Inter-individual variability in different mouse strains. Five milligrams per kilogram HF51116 was subcutaneously (s.c.) injected into C57BL/6, C3H/HEJ, and DBA/2 mice. The blood samples were collected at 30 min post-injection (mean ± SEM of n = 12 mice for the C57BL/6 and DBA/2 groups, n = 10 mice for the C3H/HEJ group). ****P < 0.0001, **P < 0.01, *P < 0.05; ns, not significant

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