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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: LncRNA NORAD promotes bone marrow stem cell differentiation and proliferation by targeting miR-26a-5p in steroid-induced osteonecrosis of the femoral head

Fig. 5

NORAD improved Dex-induced inhibition of proliferation and differentiation, and promotion of apoptosis by regulation of miR-26a-5p in hBMSCs. a The miR-26a-5p expression in hBMSCs was detected by RT-qPCR. b The bands of RUNX2, OPG, RANK, and RANKL protein was detected by western blot. cf The protein expression of RUNX2 (c), OPG (d), RANK (e), and RANKL (f) was detected by western blot. g The proliferation ability of hBMSCs was measured by the CCK-8 assay. h The flow cytometry was used to detect apoptosis in hBMSCs. **P < 0.01 compared with control group, ##P < 0.01 and #P < 0.05 compared with Dex group, &&P < 0.01 and &P < 0.05 compared with Dex+Vector+ mimics NC group, $$P < 0.01 and $P < 0.05 compared with Dex+NORAD group

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